Labs

  • The UCLA Pasarow Mass Spectrometry Laboratory is an intellectually vibrant group dedicated to the advancement of the science and training of students through innovative research and educational endeavors. As of January 2009 there are eight full-time members including two faculty, two senior technicians, two post docs, one Ph.D. students and one of undergraduate, in addition to numerous other UCLA faculty, staff and students who make frequent use of the facility and the in-house expertise. Our publication record is easily accessed via the web using Faull, KF and Whitelegge, JP as search descriptors. NSF and NIH Shared Instrument Grants over the past few years had led to the acquisition of several new instruments that complete the suite of available instrumentation. The availability of electron impact (EI), chemical (CI), atmospheric chemical ionization (APCI) and electrospray (ESI) ionization methods together in one facility is a feature of this Laboratory that is vital to the variety of chemical and biochemical research at UCLA. The Laboratory is also equipped a range of modern equipment necessary for the successful operation of a wet biochemical laboratory, including gas (capillary) and liquid chromatography (analytical, micro- and nano-bore) capability and gel electrophoresis.

  • The Molecular Screening Shared Resource (MSSR) offers a comprehensive range of leading-edge high throughput screening (HTS) services including drug discovery, chemical and functional genomics, and novel methods for nano and environmental toxicology. The MSSR is an open access environment with investigators from UCLA as well as from the entire globe. Industrial clients are equally welcome as are non-profit entities.

  • The Biological Samples Processing Core (BSPC) offers DNA extractions from whole blood and other tissue types utilizing the Autopure LS nucleic acid purification instrument from Gentra Systems. Extracted DNA can be returned immediately or stored indefinitely at the BSPC in a -20°C freezer, for future use. The core also aliquots DNA at desired concentrations. All samples are logged in the BSPC database and are bar-coded with their sample number and customer's identification code.

  • The Technology Center for Genomics & Bioinformatics (TCGB) is a fully automated, high-throughput genomic facility equipped with all major next generation sequencing and microarray platforms. TCGB provides next generation sequencing and microarray-based genomic services, including Whole genome sequencing, Whole Exon Sequencing, Whole Transcriptome Sequencind (RNA-Seq), Small RNA Sequencing (miRNA-Seq), Targeted Resequencing, Methylation Sequencing (Methy-Seq), SNP Genotyping, in a cost-effective and timely manner to serve basic science, translational, and clinical researchers

  • Provides consulting including grant preparation and timely help to researchers in the health sciences and other areas. Experineced in a wide range of applications, including clinical trials, laboratory studies, surveys, epidemilogical studies, and many others.

  • As with other areas of biomedical science, the post-genome era raises the prospect of transformational advances in neuroscience research. Neuroscience faces special challenges, however, in analysis, interpretation, and management of the vast quantities of information generated by genetic and genomic technologies. The phenotypic and organizational complexity of the nervous system calls for distinct analytical and informatics strategies and expertise. The ICNN will provide advanced analysis and informatics support to a highly interactive user group consisting of neuroscientists at UCLA, who are conducting basic, clinical, and translational research. These investigators have access to excellent facilities for genetics and genomics experimentation; the lack of corresponding resources in analysis and informatics constitutes a bottleneck in their research. ICNN faculty experts in statistical genetics, gene expression analysis, and bioinformatics will oversee the activities of highly-trained staff members who will accomplish three goals:

    Providing expert consultation and analyses for neurogenetics and neurogenomics projects;

    Developing and maintaining a shared computing resource that will include a computational cluster for computation-intensive analyses, web-servers and state of the art software tools for a wide range of applications (including user-friendly versions of public databases, as well as workstations on which ICNN users will be trained to employ these tools;

    Providing hands-on training in analysis and informatics to the users.

  • The primary objective of DOMStat is to provide state-of-the-art study design and statistical analysis collaboration to investigators in the Department of Medicine as well as faculty from across UCLA. DOMStat offers faculty and staff level statistical collaboration for grant proposals, data analysis, manuscript preparation, and other research activities requiring statistical input. We have expertise in clinical trials, high-throughput molecular analysis, observational studies, and large scale secondary data analyses.

  • The objective of the UCLA Vector Core is to promote and facilitate basic and translational research by providing investigators with access to vector technologies that enable efficient gene transfer to mammalian cells in culture and in vivo. To this end, the Vector Core is currently:

    Serving as an educational and advisory resource for UCLA researchers who may have had limited experience with virus-derived gene transfer vector technologies, but who wish to utilize such technologies for efficient functional expression of genetic sequences of interest in mammalian cell culture and in animal models in vivo

    Providing, at minimal cost, various pre-made retroviral, lentiviral, and adenoviral vector stocks expressing standard marker genes to utilize in preliminary experiments, as well as a library of available vectors expressing a variety of mammalian genes and corresponding inhibitory sequences

    Designing and producing custom viral vectors that contain a specific transgene of interest (including wild type and mutant cDNAs with or without epitope tags, dominant-negative expression constructs, antisense mRNAs, siRNAs, etc.) for individual researchers. A bank of lentiviral vectors including transfer vectors, vectors expressing marking genes and customized vectors is available.

    The Vector Core assists investigators from academia, and private companies.

  • Provides testing services, blood and blood cell products and other specialized services to research labs working with HIV and related viruses.