Labs

  • Access to NMR technology for both UCSD and external users. Users can collect their own data, facility staff can do it all for you, or collaborative projects can be developed. The facility houses two 600 MHz Bruker Avance III spectrometers with cryogenically cooled probes for enhanced sensitivity. For samples whose concentration is limited by the amount of material available, or by solubility, our 1.7 mm microcoil cryoprobe requires just 40 μl of solution. We provide training in instrument operation and can offer advice for data analysis or project feasibility.

  • The UCLA Pasarow Mass Spectrometry Laboratory is an intellectually vibrant group dedicated to the advancement of the science and training of students through innovative research and educational endeavors. As of January 2009 there are eight full-time members including two faculty, two senior technicians, two post docs, one Ph.D. students and one of undergraduate, in addition to numerous other UCLA faculty, staff and students who make frequent use of the facility and the in-house expertise. Our publication record is easily accessed via the web using Faull, KF and Whitelegge, JP as search descriptors. NSF and NIH Shared Instrument Grants over the past few years had led to the acquisition of several new instruments that complete the suite of available instrumentation. The availability of electron impact (EI), chemical (CI), atmospheric chemical ionization (APCI) and electrospray (ESI) ionization methods together in one facility is a feature of this Laboratory that is vital to the variety of chemical and biochemical research at UCLA. The Laboratory is also equipped a range of modern equipment necessary for the successful operation of a wet biochemical laboratory, including gas (capillary) and liquid chromatography (analytical, micro- and nano-bore) capability and gel electrophoresis.

  • The Molecular Screening Shared Resource (MSSR) offers a comprehensive range of leading-edge high throughput screening (HTS) services including drug discovery, chemical and functional genomics, and novel methods for nano and environmental toxicology. The MSSR is an open access environment with investigators from UCLA as well as from the entire globe. Industrial clients are equally welcome as are non-profit entities.

  • The UCLA Crystallization Facility provides state-of-the-art, high-throughput, crystallization services to all institutions. The full-service core offers access to sophisticated equipment and technologies, and technical assistance in sample preparation. The facility will provide screen preparation, plate setup, automated image acquisition and analysis, and optimization design. Our high-throughput set up can produce 18,000 experiments in a single day.

  • For more than 40 years the J.D. McCullough Laboratory of X-ray Crystallography has been in operation, providing 3-dimensional structure of small molecules in solid crystals via X-ray crystallography. The facility is also equipped for characterization of polycrystalline solid materials using powder and thin film diffraction techniques. The laboratory is a full service facility where staff deals with all aspects of service from crystal selection to publication of results. In-house training is a requirement if you wish to use the equipment yourself.

  • The Crump Institute's Preclinical Imaging Technology Center provides state-of-the-art in vivo molecular imaging technologies and related services to faculty, staff and students at UCLA. The Center functions both as a laboratory facility for imaging research and development, and as a shared preclinical imaging resource for researchers across various disciplines on campus. As a world leader in molecular imaging, the Center aims to connect state-of-the-art technologies and imaging expertise with in vivo biological applications, to allow real-time, quantitative measurement of health and disease.

  • EICN can assist you in achieving success in your research by providing state-of-the-art electron microscopy instruments and assisted usage services. Highly experienced staff provides necessary training and can help users address complex electron imaging needs. EICN offers advanced electron imaging techniques for visualizing materials, nanomachines, and cellular structures at atomic or nanometer scales in 2D and 3D. In addition, our latest integrated iCorr technology enables a streamlined approach to correlative microscopy to perform both fluorescence light and electron microscopy for biological research.

  • The Immune Assessment Core is a comprehensive source of immune assessment testing services for basic, clinical and translational studies. The full service laboratory performs various immunological assays to evaluate the innate and adaptive immune status of study subjects.

    The Immune Assessment Core focuses on developing assays using cutting edge, high throughput technologies. We obtain the highest quality data to survey the immune system using small sample volumes. This is achieved by providing validated assays with multiplexed capacities. We work closely with our clients to assist with analysis and interpretation of the comprehensive data sets to ensure they get the most out of the samples they have collected. In addition to the above mentioned assays, the core performs customized assay development to meet the client's developing needs.

  • The Embryonic Stem Cell/Transgenic Mice Shared Resource provides a multi-tiered service to accommodate individual investigators' needs in the production of transgenic mice, using pronuclear injection; targeted genetic alterations in embryonic stem (ES) cells and murine strains derived from ES cells with targeted mutations. The mission of the ES Cell/Transgenic Mice Shared Resource is to provide these services with high standards of quality control in a cost-effective manner. The ES Cell/Transgenic Mice Shared Resource provides advice to investigators in the design and assembly of DNA constructs, on the availability of transgenic animal models and for evaluating and implementing new methodologies as they arise. In addition to providing consulting services, the ES Cell/Transgenic Mice Shared Resource provides materials (expression vectors, quality-assured ES cells, batch-tested sera and reagents) to investigators opting to undertake these projects in their own laboratories. The ES Cell/Transgenic Mice Shared Resource has two facilities: in addition to providing advice and reagents, the ES Cell Culture Facility will perform electroporations and select and maintain targeted ES cell lines for individual investigators; and the Transgenic/KO Injection Facility of the shared resource performs pronuclear injections of DNA and blastocyst injections of targeted ES cells, and maintains transgenic animal lines in their initial stages.